The Effect of Familial Mediterranean Fever Disease on The Cornea

Objective: To investigate corneal structural in patients with Familial Mediterranean Fever (FMF). Methods: This case-control study included 64 FMF and, 49 age and gender similar healthy subjects without any eye disease. Endothelial cell density (ECD), the coefficient of variation size (CV) percentage hexagonality were measured by non-contact specular microscopy, central thickness (CCT) was ultrasonic pachymetry. Results: The mean CCT value 516.89± 32.23 μm group 545.12±24.56 control group. ECD, CV, values 3402.51±383.84 cells/mm², 26.72±4.55%, 68.60±8.63%in group, respectively 3339.46±322.60 27.59± 5.23%, 67.34± 9.38% respectively. Of these parameters, statistically significantly different between groups (p = 0.011). Conclusion: Compared to individuals, may have significant morphological changes structure cornea.